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Reviews in Pharmaceutical Sciences

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Reviews in Pharmaceutical Sciences

Big Science Publishers LLP (registered under section 12(1) of the LLP act 2008) is a fully open access non-annual journal, publish high quality science-based review and research articles. Big Science Publishers also guide the young budding researchers, UG/PG students and scholars and other academic professional who wants to learn the manuscript writing.


Publications Easy under the aegis of Big Science Publishers provide the guidance and take the short tutorial classes to teach the basics to advanced level manuscript writing, supporting tools, finding the right journal, and other related advice to bring the quality manuscript.

Home Articles Volume 1, Issue 2 Aquasomes in Drug Delivery: Opportunities, Challenge...
Review

Aquasomes in Drug Delivery: Opportunities, Challenges, and Future Perspectives

Shahana BC 1, a
Volume 1 , Issue 2 , 2025-11 , Pages 01-13
Open Access
Open Access
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/

History

Received: 2025-11-03
Accepted: 2025-11-21
Available Online: 2025-11-28

Abstract

Aquasomes are a novel type of self-assembling, nanoparticulate carriers that provide unique benefits for the targeted delivery of bioactive substances like proteins, peptides, hormones, antigens, and genes. These spherical particles, which measure between 60 and 300 nm in diameter, and a bioactive molecule that is adsorbed onto the surface. The formation of aquasomes is influenced by non-covalent and ionic interactions, resulting in a stable and effective structure for delivering drugs. The solid core contributes to the particle's structural integrity and stability, while the carbohydrate layer serves as a protective barrier against dehydration, thereby maintaining the activity of sensitive biomolecules. Aquasomes have demonstrated significant effectiveness in delivering therapeutic agents such as insulin, hemoglobin, and enzymes like serratiopeptidase, as well as other biologically active substances, with applications in both small- molecule and biologic drug delivery. This review examines the principles that govern aquasome, the difficulties involved in preserving the conformational integrity and biochemical activity of immobilized molecules, and how these principles converge to create an effective drug delivery system. Furthermore, the review underscores the wide-ranging applications of aquasomes across different pharmaceutical sectors, highlighting their potential as a versatile and stable platform for the targeted delivery of therapeutic agents. Future outlooks and ongoing challenges in the advancement of aquasomes for clinical applications are also explored.

Subject

Pharmacy

Article Type

Review

Keywords

Aquasomes Vesicular Nanoparticulate carrier Three layered Self Assembly

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Journal
Journal Reviews in Pharmaceutical Sciences
Volume Volume 1
Issue Issue 2
Year 2025

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