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Organophosphate (OP) compounds represent one of the most significant neurotoxicological threats in modern society, with exposure occurring through pesticide use, chemical warfare agents, and industrial processes. Our research program employs a comprehensive, multidisciplinary approach to understand the complex neurobehavioral consequences of OP poisoning and develop effective therapeutic interventions. This editorial outline our integrated methodology combining behavioural assessment, proteomics analysis, advanced imaging techniques, and novel drug delivery systems to advance the field of neurotoxicology.